pI: 8.4122 |
Length (AA): 586 |
MW (Da): 63642 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
51 | 169 | 4dk1 (A) | 125 | 244 | 25.00 | 0.18 | 0.72 | 0.348372 | 1.03 |
356 | 506 | 5apg (A) | 2 | 155 | 38.00 | 0 | 1 | 0.669479 | -0.81 |
379 | 530 | 5apg (A) | 33 | 179 | 34.00 | 0 | 1 | 0.709586 | -0.6 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | ME49 merozoite. | Hehl AB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 Oocyst, ME49 Bradyzoite. | Gregory Fritz HM Sibley/Greg |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Sibley/Greg | ToxoDB |
Ortholog group members (OG5_127734)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G10070 | RNase L inhibitor protein-like protein |
Babesia bovis | BBOV_III005390 | metal-binding domain in RNase L inhibitor, RLI family protein |
Brugia malayi | Bm1_36350 | Possible metal-binding domain in RNase L inhibitor, RLI family protein |
Candida albicans | CaO19.5802 | similar to S. cerevisiae YOR006C |
Candida albicans | CaO19.13224 | similar to S. cerevisiae YOR006C |
Caenorhabditis elegans | CELE_F52C12.2 | Protein F52C12.2 |
Cryptosporidium hominis | Chro.80186 | hypothetical protein |
Cryptosporidium parvum | cgd8_1580 | saccharomyces Yor006cp like protein conserved across euks and archaea |
Dictyostelium discoideum | DDB_G0267822 | hypothetical protein |
Drosophila melanogaster | Dmel_CG4338 | CG4338 gene product from transcript CG4338-RA |
Echinococcus granulosus | EgrG_000379200 | methyltransferase protein 6 |
Entamoeba histolytica | EHI_100490 | hypothetical protein, conserved |
Echinococcus multilocularis | EmuJ_000379200 | methyltransferase protein 6 |
Giardia lamblia | GL50803_16463 | RNase P RNA component |
Homo sapiens | ENSG00000007520 | TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) |
Leishmania braziliensis | LbrM.32.2170 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_322090.1 | ribosome biogenesis protein TSR3, putative |
Leishmania infantum | LinJ.32.2090 | hypothetical protein, conserved |
Leishmania major | LmjF.32.1970 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.31.1970 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_02552 | hypothetical protein |
Mus musculus | ENSMUSG00000015126 | TSR3 20S rRNA accumulation |
Neospora caninum | NCLIV_020710 | hypothetical protein |
Oryza sativa | 4331931 | Os03g0195200 |
Plasmodium berghei | PBANKA_1435700 | ribosome biogenesis protein TSR3, putative |
Plasmodium falciparum | PF3D7_1220500 | ribosome biogenesis protein TSR3, putative |
Plasmodium knowlesi | PKNH_1439700 | ribosome biogenesis protein TSR3, putative |
Plasmodium vivax | PVX_123665 | ribosome biogenesis protein TSR3, putative |
Plasmodium yoelii | PY06626 | hypothetical protein |
Saccharomyces cerevisiae | YOR006C | Tsr3p |
Schistosoma japonicum | Sjp_0100440 | ko:K00599 methyltransferase like 6 [EC:2.1.1.-], putative |
Schistosoma mansoni | Smp_042650 | hypothetical protein |
Schmidtea mediterranea | mk4.000723.11 | Ribosome biogenesis protein TSR3 homolog |
Trypanosoma brucei gambiense | Tbg972.11.17050 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.11.15170 | ribosome biogenesis protein TSR3, putative |
Trypanosoma congolense | TcIL3000.11.15340 | ribosome biogenesis protein TSR3, putative |
Trypanosoma cruzi | TcCLB.503987.70 | ribosome biogenesis protein TSR3, putative |
Trypanosoma cruzi | TcCLB.511713.40 | ribosome biogenesis protein TSR3, putative |
Toxoplasma gondii | TGME49_204540 | DUF367 domain-containing protein |
Theileria parva | TP02_0408 | hypothetical protein |
Trichomonas vaginalis | TVAG_172490 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.6830 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.6830 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.6830 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.6830 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_204540 this record | Toxoplasma gondii | Essentiality uncertain | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.